Tendencia de la seroprevalencia de marcadores del virus de la hepatitis B en donantes del Paraguay en el periodo 2012 a 2023. Un abordaje retrospectivo a nivel nacional

Nathalia Navarro; Margarita Samudio; Nelson Marqués Roa; Anibal Espínola Cano; Jimena Casco Cantero; Cecilia Gonzalez Vatteone; Pamela Mancuello; Leticia Rufinelli Arce; Amanda Carolina Molas

doi:10.52379/mcs.v10.615

Authors

Nathalia Navarro Universidad Nacional de Asunción. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica.
Margarita Samudio Universidad del Pacífico
Nelson Marqués Roa Ministerio de Salud Pública y Bienestar Social. Programa Nacional de Sangre
Anibal Espínola Cano Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Asunción, Paraguay
Jimena Casco Cantero Universidad Nacional de Asunción. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica
Cecilia Gonzalez Vatteone Universidad Nacional de Asunción. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica.
Pamela Mancuello Universidad Nacional de Asunción. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica.
Leticia Rufinelli Arce Universidad Nacional de Asunción. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica.
Amanda Carolina Molas Ministerio de Salud Pública y Bienestar Social. Programa Nacional de Sangre

Keywords:

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Abstract

Introduction: Hepatitis B virus infection has been declared a major public health problem by the World Health Organization. It is a potentially fatal disease. Preventing transmission through blood transfusions presents one of the greatest challenges; therefore, serological and molecular screening is performed to minimize risks. Objective: To evaluate the seroprevalence trend of hepatitis B virus markers in donors from Paraguay. Methodology: A retrospective cross-sectional descriptive study was carried out in which the seroprevalences of the central antigen (anti-HBc) and surface antigen (HBsAg) of the hepatitis B virus of adult donors registered in the National Blood Services System of Paraguay in the period 2012-2023 were analyzed. Results: From 2012 to 2023, 1.165.486 blood units were collected. The overall seroprevalence for the HBsAg marker was 0.33% (n=43,834), with a stable trend over time (r2=0.05; p=0.504). For the Anti-HBc antibody, the overall seroprevalence was 2.38% (n=27,707), with a downward trend (r2=0.80; p<0.001). Conclusion: Despite the stable and downward trends in reported seroprevalence in donors, the importance of centralizing data at the national level, the use of highly sensitive and specific detection tests, and the need to adopt preventive measures such as immunization in donors are highlighted.

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