Patterns and Trends of Antimicrobial Resistance in Staphylococcus aureus Isolated in a Private Laboratory in Paraguay from 2020 to 2024
DOI:
https://doi.org/10.52379/mcs.v9.598Keywords:
Staphylococcus aureus, Methicillin resistance, Multidrug ResistanceAbstract
Introduction: Staphylococcus aureus, a pathogen of global concern, has the ability to develop antimicrobial resistance, a factor that demands continuous surveillance. Objective: The objective was to determine the patterns and trends of antimicrobial resistance of S. aureus isolated from purulent secretions of patients attended at a private laboratory in Paraguay between 2020 and 2024. Methodology: This was a descriptive, retrospective study that used data from the electronic database of a private laboratory for the statistical analysis of variables such as antimicrobial susceptibility of S. aureus, from purulent secretion culture requests between 2020 and 2024. Results: S. aureus was isolated in 28.6% (220/770). Of these, 56.8% (n=125) were resistant to methicillin. A total of 61.5% (n=88) of the isolates were from outpatients. A moderate correlation was observed between methicillin resistance and resistance to ciprofloxacin (R²=0.709) and erythromycin (R²=0.705). The isolates showed resistance to erythromycin (66%), ciprofloxacin (34%), clindamycin (32%), and gentamicin (19%), but were 100% susceptible to trimethoprim-sulfamethoxazole and vancomycin. Among the multidrug resistance patterns in methicillin-resistant S. aureus, co-resistance to erythromycin-ciprofloxacin (37.5%) stood out. Conclusion: The increasing resistance to erythromycin, ciprofloxacin, and clindamycin limits their use in empirical treatments and highlights the importance of improving epidemiological surveillance strategies
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Copyright (c) 2025 Julio César Barrios Leiva, Margarita Samudio Acevedo, Rosa María Guillén Fretes, Norma Fariña, Ana Vega, Alicia Pereira Fariña, Fátima Rodríguez Acosta
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